Pretty normal side effects. Temperature of less than 100.5 is ok, much higher call your doc. Urgency, razor blades voiding, aches, fatigue, spasms are all normal and become cumulative as you go. The good news they do subside. For me it was all ok usually by the second day. Should these become really bad dosage can be reduced to 1/2, 1/3, 1/4 and usually the same coverage. This is was better than systemic chemo!