Delayed side effects with Mitomycin

4 years 9 months ago #57726 by Alan
Replied by Alan on topic Delayed side effects with Mitomycin
Wow! Thanks for posting. As mentioned earlier I have not read about such a delayed reaction but, I have learned many things are possible and as soon as I think I have seen it all here comes another change! You are correct nonetheless, that is good news I just hope you heal completely very soon.

DX 5/6/2008 TAG3 papillary tumor .5 CM in size. 2 TURBS followed by 6 instillations of BCG weekly with a second round of 6 after a 6 week wait.

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4 years 9 months ago #57724 by HTXfire
Replied by HTXfire on topic Delayed side effects with Mitomycin
My pathology report came back this morning and the Dr suspects I had a severe inflammatory response.

Bladder mass biopsies:
- Hemorrhagic cystitis.
- Urothelial hyperplasia with atypia, favor reactive.

This is good news, considering this time last week I thought I had another tumor. I’m still in a lot of pain though. I’ve almost finished my anti-inflammatory pack and I’m wondering if 7 days was long enough. Anyone else experienced hemorrhagic cystitis? I’m a very active 34yo male and it has kicked me to my knees. I still find it odd that I had such a delayed reaction to a single dose of localized chemo in my bladder following my first TURBT.

Would love to hear others thoughts and experiences...

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4 years 9 months ago #57722 by sara.anne
Replied by sara.anne on topic Delayed side effects with Mitomycin
Yes, it is very common to have both papillary and CIS. I did. This is the same cancer, just a different form, arising from transitiional cells in the bladder wall.

Sara Anne

Diagnosis 2-08 Small papillary TCC; CIS
BCG; BCG maintenance
Vice-President, American Bladder Cancer Society
Forum Moderator

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4 years 9 months ago #57721 by HTXfire
Replied by HTXfire on topic Delayed side effects with Mitomycin
So you can have both papillary urethral carcinoma & flat carcinomas CIS or SITU. Is that common? I’ll be sure and update my path report results here. Thanks for the reply Alan.

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4 years 9 months ago #57717 by Alan
Replied by Alan on topic Delayed side effects with Mitomycin
HTXfire,

Welcome. I just wanted to acknowledge your post has been seen. I have not read about anyone with a 2 month delay on reaction to any of the usual agents be it BCG or mitomycin or others. I say this risking not to give you anymore concern than you already have, this could be a severe reaction of some sort or CIS which is a flat like rash which is cancer. The pathology report should give some closure on this. Please keep us posted as well all learn from each other.

DX 5/6/2008 TAG3 papillary tumor .5 CM in size. 2 TURBS followed by 6 instillations of BCG weekly with a second round of 6 after a 6 week wait.

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4 years 9 months ago #57715 by HTXfire
Delayed side effects with Mitomycin was created by HTXfire
Hello, two months ago I had a 1cm tumor removed during TURBT. I received an immediate Mitomycin dose after the procedure and woke up with the drug inside a catheter. Once I was home I bled and had painful urination for about one week and was back to 100%. I went on about my normal life and out of no where intense/constant penile pain (I assume from clots that were stuck) bleeding, and painful urination, as well as passing clots. I went to the ER twice over 3 days. CT scan showed a new 2cm tumor, urologist without scoping me scheduled another TURBT. Once inside he doesn’t see a tumor, but only severe inflammation of my bladder. I believe what the ER doctor was viewing was a large clot. So, now I’m home recovering from a second TURBT, doctor biopsied a few patches and I’m awaiting path report. My question is whether or not anyone has experienced a delayed ( 2mo in my case) reaction of inflammation in the bladder, painful urination, and clots forming from a single dose of Mitomycin? If not, how did you handle Mitomycin? I saw pictures from my TURBT and my bladder looks angry.

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