Sorafenib Clinical Trial

Hi,

I haven't met anyone who has tried this drug or participated in the trial, it's very new. I looked around a bit, found a recent (aug.'06) lecture on new drugs for metastatic bladder cancer that mentioned Sorafenib:
www.cancerlectures.com/other_solid_tumors/kbcc/index.html

Scroll down to:
Novel Agents in Bladder Cancer- Moderator: Walter Stadler
Video/lecture: VEGF Inhibitors: Current Data, Jonathan Rosenberg

The lecture states that those who test positive for the RAF marker are rare, and that it's most likely the VEGF/anti-angiogenic qualities of Sorafenib that can help bladder cancer. From my understanding it would be a lot less toxic than chemo as a single agent (I noticed the lecture mentions it in trials combined with chemo). Maybe it will be the thing for your father, I certainly hope so.

Seems to me your father's doctor is extremely cutting edge.
All the best,
Wendy

My father was diagnosed with T4 bladder cancer in Fall'05...he had his bladder and prostate removed, and a neo-bladder constructed. We've had some post-op problems with proper kidney function - high creatin levels (issue might have been the result of radiation treatment in the mid-1970's after testicular cancer), and he has a catheter and nephrostomy tube at present.
His most recent CT-scan confirmed a 'recurrence' of multiple cancer cells, ranging in size (largest: 18mm) in/on the abdominal wall and ilial branches (details are 'sketchy', getting a copy of the CT results soon).
He met with his Oncologist today - Dr. S. Hotte, Juravinski Cancer Centre, Henderson Hospital, Hamilton, ON. - who has given him options: chemo or test and take part in a clinical trial of BAY 43-9006 (www.cancer.gov/clinicaltrials/PMH-PHL-036)
Does anyone have any experience with this trial/drug?