I have completed my original 6 infusions of BCG as well as my first cycle of 3 treatments that are scheduled every 3 months for 2 yrs. The more treatments I've received, the harder the side effects. The first 6 were virtually unremarkable, except for the frequency. Wish I could say the same for the last 3. Each one had the normal, fatigue, burning and frequency with bladder spasms. They each went away within 5 days, just to be ready for another treatment. After my 9th treatment, I had the same symptoms but with a lot of pressure in my perineal area. The burning and frequency improved as with the other treatments but the spams and pressure did not leave me until 3 and a half weeks. The pressure felt like my bladder was falling out. The more I was on my feet, the worse it got. I lived on Azo (which is the generic for Pyridium and Ibuprofen or stronger for weeks. My tolerance is really strong, I'm a past cancer survivor times 2, each with chemotherapy and radiation with the first. My frequency continued every 2 hours for the 3 and a half weeks also. It's been 4 weeks since my last treatment and I can now say I feel back to my normal self. I had called my Dr after 10days, he ordered a culture of my urine which was negative with no suggestion for relief. I have a cysto in 3 wks, when my Uro Dr and I have to have a long chit chat cause I am thinking this was alittle extreme.